The thymus is a unique primary lymphoid organ that supports the production of self‐tolerant T‐cells essential for adaptive immunity. Intrathymic microenvironments are microanatomically compartmentalised, forming defined cortical, and medullary regions each differentially supporting critical aspects of thymus‐dependent T‐cell maturation. Importantly, the specific functional properties of thymic cortical and medullary compartments are defined by highly specialised thymic epithelial cells (TEC). For example, in the medulla heterogenous medullary TEC (mTEC) contribute to the enforcement of central tolerance by supporting deletion of autoreactive T‐cell (...) clones, thereby counterbalancing the potential for random T‐cell receptor generation to contribute to autoimmune disease. Recent advances have further shed light on the pathways and mechanisms that control heterogeneous mTEC development and how differential mTEC functionality contributes to control self‐tolerant T‐cell development. Here we discuss recent findings in relation to mTEC development and highlight examples of how mTEC diversity contribute to thymus medulla function. (shrink)

Why do black families own less than white families? Why does school segregation persist decades after Brown v. Board of Education? Why is it harder for black adults to vote than for white adults? Will addressing economic inequality solve racial and gender inequality as well? This book answers all of these questions and more by revealing the hidden rules of race that create barriers to inclusion today. While many Americans are familiar with the histories of slavery and Jim (...) Crow, we often don't understand how the rules of those eras undergird today's economy, reproducing the same racial inequities 150 years after the end of slavery and 50 years after the banning of Jim Crow segregation laws. This book shows how the fight for racial equity has been one of progress and retrenchment, a constant push and pull for inclusion over exclusion. By understanding how our economic and racial rules work together, we can write better rules to finally address inequality in America. (shrink)

In an online, participatory class, we interpreted The Dream of the White House knowing nothing of the dreamer and having none of the dreamer’s associations. Our interpretation included a series of falsifiable predictions about the dreamer. When it was complete, we asked the bringer of the dream (who had until then been silent and was not visible to us) to give us more information about the dreamer. Of 17 predictions 15 were confirmed. The dreamer suffers dislocation and loss until (...) she asks a female manager for help. This record is another iteration of an experiment that will be described more fully in the paper 'The Dream of the Six-Legged Dog: An Experimental System to Test Meaning,' soon to be published. This iteration repeats and confirms the evidence given in that paper. More than any of the other iterations, it details how talk therapy promotes personality reorganization. It then supports these observations with experimental evidence. Because it demonstrates how talk therapy works, this iteration supports talk therapy against pressure from the drug and insurance corporations. AUDIO-RECORDING OF WHOLE CLASS: link provided on first page of the paper you download here. (shrink)

Precision targeting of specific white matter bundles that traverse the subcallosal cingulate has been linked to efficacy of deep brain stimulation for treatment resistant depression. Methods to confirm optimal target engagement in this heterogenous region are now critical to establish an objective treatment protocol. As yet unexamined are the time-frequency features of the SCC evoked potential, including spectral power and phase-clustering. We examined these spectral features—evoked power and phase clustering—in a sample of TRD patients with implanted SCC stimulators. Electroencephalogram (...) was recorded during wakeful rest. Location of electrical stimulation in the SCC target region was the experimental manipulation. EEG was analyzed at the surface level with an average reference for a cluster of frontal sensors and at a time window identified by prior study. Morlet wavelets generated indices of evoked power and inter-trial phase clustering. Enhanced phase clustering at theta frequency was observed in every subject and was significantly correlated with SCC-EP magnitude, but only during left SCC stimulation. Stimulation to dorsal SCC evinced stronger phase clustering than ventral SCC. There was a weak correlation between phase clustering and white matter density. An increase in evoked delta power was also coincident with SCC-EP, but was less consistent across participants. DBS evoked time-frequency features index mm-scale changes to the location of stimulation in the SCC target region and correlate with structural characteristics implicated in treatment optimization. Results also imply a shared generative mechanism between evoked potentials evinced by electrical stimulation and evoked potentials evinced by auditory/visual stimuli and behavioral tasks. Understanding how current injection impacts downstream cortical activity is essential to building new technologies that adapt treatment parameters to individual differences in neurophysiology. (shrink)

The general aim of this paper is to provide insight into the relevance of critical phenomenology for the study of the patient-provider relationship in health care systems in U.S. jails, prisons, and detention facilities. In particular, I utilize tools from the work of scholars studying phenomenological approaches to health care and structural forms of oppression to analyze several harms that arise from the provision of medical care under the punitive constraints of carceral facilities.

Examines Bergson's work from the perspectives of critical philosophy of race and decolonial theory, placing it in conversation with theorists from Africa, the African Diaspora, and Latin America.

In this article, I examine the relationship between self-knowledge practices among women of color and structural patterns of ignorance by offering an analysis of Gloria E. Anzaldúa's discussions of self-writing. I propose that by writing about her own experiences in a manner that hails others to critically interrogate their own identities, Anzaldúa develops important theoretical resources for understanding self-knowledge, self-ignorance, and practices of knowing others. In particular, I claim that in her later writings, Anzaldúa offers a rich epistemological account of (...) these themes through her notion of autohistoria-teoría. The notion of autohistoria-teoría demonstrates that self-knowledge practices, like all knowledge practices, are social and relational. Moreover, such self-knowledge practices require contestation and affirmation as well, including, resistance and productive friction. (shrink)

Perceptions of a firm’s stance on corporate social responsibility (CSR) are influenced by its corporate marketing efforts including branding, reputation building, and communications. The current research examines CSR from the consumer’s perspective, focusing on antecedents and consequences of perceived CSR. The findings strongly support the fact that particular cues, namely perceived financial performance and perceived quality of ethics statements, influence perceived CSR which in turn impacts perceptions of corporate reputation, consumer trust, and loyalty. Both consumer trust and loyalty were also (...) found to reduce the perceived risk that consumers experience in buying and using products. From these significant findings, we draw several conclusions and implications, including the importance of enhancing firm focus toward its ethical commitment and long-term reputation. (shrink)

This volume brings together many prominent philosophical voices today focusing on issues of U. S. Latinx and Latin American identities and feminist theory. As such, the essays collected here highlight the varied and multidimensional aspects of gender, racial, cultural, and sexual questions impacting U.S. Latinx and Latin American communities today. The collection also highlights a number of important threads of analysis from fields as diverse as disability studies,aesthetics, literary theory, and pop culture studies.

This paper argues that debates regarding legal protections to preserve the privacy of data subjects, such as those involving the European Union’s right to be forgotten, have tended to overlook group-level forms of epistemic asymmetry and their impact on members of historically oppressed groups. In response, I develop what I consider an abolitionist approach to issues of digital justice. I begin by exploring international debates regarding digital privacy and the right to be forgotten. Then, I turn to the long history (...) of informational asymmetries impacting racialized populations in the United States. Such asymmetries, I argue, comprise epistemic injustices that are also implicated within the patterns of racialized incarceration in the United States. The final section brings together questions regarding the impact of such epistemic injustices on incarcerated peoples and focuses specifically on the public availability of criminal histories in online search databases as a fundamental issue within conversations regarding digital justice. I thus conclude by building from the work of contemporary abolitionist writers to argue that the underlying concerns of an individualized right to be forgotten should be transformed into a collective effort to undermine societal carceral imaginaries. (shrink)

Philosophers have long endeavored to support politically relevant efforts, including institutional and legal reforms, insurrectionist uprisings, anticolonial independence struggles, cultural movements, and anti‐violence work. While some debates have emerged regarding normative questions of whether or how philosophers should be activists, this chapter focuses more directly on the manner in which philosophical authors have supported, engaged in, or examined forms of political participation that seek to end forms of oppression such as racism, sexism, colonialism, and systemic poverty. It distinguishes between philosophers (...) who are writing about or in support of forms of political activism and social movements. The chapter explores specific activists and movements that have become relevant within academic philosophy. It examines philosophers who have engaged in direct political action while working within academic philosophy. (shrink)

From Greek antiquity to the latest theories, this historical survey of political philosophy not only covers the major thinkers in the field but also explores the theme of how political philosophy relates to the nature of man. It illustrates how the great political thinkers have always grounded their political thought in what the author terms a "normative anthropology," which typically has not only ethical but metaphysical and/or theological components. Starting with the ancient Greek Sophists, author Michael J. White examines (...) how thinkers over the centuries have approached such political and philosophical concerns as justice, morality, and human flourishing, offering substantial studies of--among others--Plato, Aristotle, Cicero, Locke, Hobbes, Rousseau, Marx, and J. S. Mill. White highlights the impact of Christianity on political philosophy, illustrating the diversity of that impact by studies of Augustine, Aquinas, and Marsilius of Padua. Concluding with an in-depth analysis of John Rawls and contemporary liberal political philosophy, this text blends insight and information in a refreshing and useful manner. A brief Epilogue considers both the value and the limitations of political philosophy and its study. (shrink)

This chapter examines truthfulness, or veracity, in the context of health care services within prisons, jails, and detention facilities in the United States. Mainstream discussions of bioethics often highlight the general importance of veracity within the patient-provider relationship, including providers’ obligations and constraints with respect to telling the truth to their patients, and, to a lesser extent, patients’ responsibilities and concerns regarding truthful reporting to their providers. However, a great deal of this literature largely overlooks how structural barriers to health (...) care impact the functions of veracity in the provision of health care—including racist and sexist biases in clinical judgment, inadequate staffing, infrastructure, and accessibility in medical facilities, and institutionally specific constraints. Through an analysis of Assata Shakur’s political autobiography, this chapter focuses on such structural barriers to health care in carceral facilities with a focus on the institutionally specific constraints that arise through the punitive aims of carceral facilities. By focusing on the intersection between punishment and health, this chapter argues that bioethicists and clinicians alike would be better equipped to analyze structural barriers to health care that exist both within and beyond prison walls through a nonideal approach. (shrink)

This paper examines conceptions of truth and “the human” in an effort to engage contemporary discussions of neointerventionism. A central question in the paper is whether one facet of the self‐justifying structure of neointerventionism is an operative framing of theories of truth underlying the explanans sought by foreign policy officials and state actors. To address this question, I turn to an unlikely source within philosophy of language, neopragmatist theorist Richard Rorty, to offer an example of an antirepresentationalist and nonobjectivist description (...) of truth that may help explain the terms and stakes of neointerventionist policies. My claim, however, will be, following the critical insights of Cornel West, Chantal Mouffe, and Sylvia Wynter, that neopragmatist efforts of the sort outlined by Rorty, while sophisticated in their analyses of the nature of truth and forms of justification, fail to thoroughly engage the political conception of “the human” that orders and frames debates regarding objectivity and solidarity. I conclude by returning to the problematic of neointerventionism from Wynter’s framings of what she calls the “coloniality of truth” and “embattled humanisms.”. (shrink)

Taking its direction from references to Black and Indigenous struggles present in Leonard Harris’ oeuvre, this chapter turns to politicized acts of resistance among Black and Indigenous communities. More specifically, the essay traces the functions of cultural pluralism, value relativism, and representative heuristics within solidarity work that enact logics of resistance to settler colonization and anti-Black racism, among other forms of oppression. Through this analysis, we see that Harris’ views about insurrection and normativity entail that both oppression and resistance are (...) the result of multiplicitous forms of agency. (shrink)

In this project, I combine theoretical resources from metaethics and philosophy of language with contemporary issues in critical philosophy of race. Drawing from these literatures, I examine the nature of racial norms by developing a non-ideal, situated, and intersectional approach to second-personhood. Second-personhood, as I propose in the first half of the dissertation, serves two explanatory functions with respect to the nature of racial norms. First, second-personhood highlights how manifestations of moral and political agency are embedded in interdependent forms of (...) I-you and we-you relationships. Second, with respect to language, second-personhood provides an account of how speech acts, when understood as a subset of embodied action, come to bear normative force. These features of second-personhood then undergird the three distinct sites of analysis that I examine in the latter half of the dissertation. There, I propose that we can examine collective, interpersonal, and personal levels of racial discourse to see the functioning of racial norms through second-personhood. (shrink)

In this paper, I examine the writings of African American philosopher Leonard Harris as an author who has been read primarily for his contributions to the study of Africana philosophy, U.S. pragmatism, and moral philosophy. Despite contributions to bioethics and reflections on systemic racism within the context of institutional medical settings, Harris’s work has yet to be read in terms of its relevance for disability critique. This paper demonstrates how Harris’s writings may be read as contributing to the field of (...) philosophy of disability by arguing that his concept of “necro-being” helps reveal the mutually reinforcing relationships between race, disability, gender, and class. To carry this out, I consider core themes from his work such as metaphilosophy, health, and autonomy to show the relevance of his writings for philosophy of disability, and, in a parallel manner, the importance of disability critique for expanding his accounts of oppression and racism. (shrink)

This paper discusses the complex relationship of Reformed confessions and Reformed orthodox scholasticism. It is argued that Reformed confessions differ in genre and method from Reformed scholastic works, although such differences between confessional and scholastic language should not be mistaken for representing different doctrines that are no longer in harmony with each other. What is more, it is precisely the scholastic background and training of the authors of such confessions that enabled them to place their confessional writings in the broader (...) catholic tradition of the Christian church and to include patristic and medieval theological insights. Thus proper attention to their scholastic background helps to see that at least in some confessions the doctrine of predestination, for instance, is not as ‘rigid’ as one might think at first sight. In order to demonstrate that the doctrine of the Reformed confessions was much in line with the scholastic theology of Reformed orthodoxy, this paper discusses, after having explained the terms ‘Reformed orthodoxy’ and ‘scholasticism’, the early Reformed scholastic theologians Beza, Zanchi, and Ursinus, who also have written confessional texts. The paper also includes a more detailed discussion of the Belgic Confession and the scholastic background of the Canons of Dordt and the Westminster Confession, thereby focusing on the doctrines of God, providence, and predestination. (shrink)

In jurisdictions where voluntary assisted dying is legal, eligibility assessments, prescription and administration of a VAD substance are commonly performed by senior doctors. Junior doctors’ involvement is limited to a range of more peripheral aspects of patient care relating to VAD. In the Australian state of Victoria, where VAD has been legal since June 2019, all health professionals have a right under the legislation to conscientiously object to involvement in the VAD process, including provision of information about VAD. While this (...) protection appears categorical and straightforward, conscientious objection to VAD-related care is ethically complex for junior doctors for reasons that are specific to this group of clinicians. For junior doctors wishing to exercise a conscientious objection to VAD, their dependence on their senior colleagues for career progression creates unique risks and burdens. In a context where senior colleagues are supportive of VAD, the junior doctor’s subordinate position in the medical hierarchy exposes them to potential significant harms: compromising their moral integrity by participating, or compromising their career progression by objecting. In jurisdictions intending to provide all health professionals with meaningful conscientious objection protection in relation to VAD, strong specific support for junior doctors is needed through local institutional policies and culture. There are no data in this work. (shrink)

White climate ethicists have a responsibility to learn, teach, and write about the intersections between climate change and white supremacy. Learning from Andrea Smith’s understanding of white supremacy as three pillars—commodification, orientalism, and genocide—built from heteropatriarchy, this essay argues that white climate ethicists should focus on particular experiences rather than universal narratives; learn from histories of colonization, slavery, and genocide; and support coalitions that empower people of color and indigenous communities. A focus on the writings (...) of scholars from marginalized identities leads to an understanding of climate change as atmospheric defilement. (shrink)

Trans philosophy—like everything else—has a history. The 1990s was a pivotal decade for the academic development of trans philosophy in the United States and Canada. During this period, the broader interdisciplinary field of transgender studies was beginning to emerge, and professional philosophy’s own contributions to transgender studies were starting to take shape as well. In what follows, we hear from Talia Mae Bettcher, Loren Cannon, Miqqi Alicia Gilbert, and Jacob Hale, four trans philosophers whose writings and activism helped provide the (...) contours of what is now becoming a robust and thriving area of study within academic philosophy. (shrink)

This paper reframes the futility debate, moving away from the question “Who decides when to end what is considered to be a medically inappropriate or futile treatment?” and toward the question “How can society make policy that will best account for the multitude of values and conflicts involved in such decision-making?” It offers a pragmatist moral epistemology that provides us with a clear justification of why it is important to take best standards, norms, and physician judgment seriously and a clear (...) justification of why ample opportunity must be made for patients, families, and society to challenge those standards and norms. (shrink)

This paper discusses the “blended identity” of online rock fans to show that the standard dichotomy between anonymous and real life personas is an inadequate description of self-presentation in online communities. Using data from an ethnographic, exploratory study of an online community and comparison groups including interviews, an online questionnaire, fan discussion boards, and participant/observation, the research analyzes fan identity online and then offline. Rolling Stones fans often adopt names that illustrate their allegiance to the band, along with avatars. Issues (...) of gender and the technological change of software platform also affect types of online self-presentations and their construction. Fans engage in “role embracement”, merging their individual selves with the role of Stones fans, demonstrated by reactions of friends and family. Connections between offline and online settings occur, with band affiliation of fans expressed through choice of apparel offline, and usernames from online filtering into the offline interactions among fans. (shrink)

Weaving together a diverse range of scholarly-activist intersectional voices from around the world, Critical Animal Studies and Activism: International Perspectives on Total Liberation and Intersectionality co-edited by Anthony J. Nocella II and Richard J. White makes a powerful contribution to knowledge and understanding. It is essential reading for environmentalists, animal advocates, social justice organizers, policy-makers, social change-makers, and indeed for all those who care about the future of this planet. This book spans many scholar disciplines and activist social movements, (...) and provides new insights to fundamental debates surrounding inter-species justice, liberation, and democracy. This critical theory for total liberation book expands the understanding of one struggle one fight: for human freedom, for animal rights, and for the liberation of the earth herself. Rooted in a radical praxis, the book argues that those in academia that claim critical animal studies, need to hit the streets with the protesters and the protesters need to join the theoretical conversations. Theory and practice and not binaries, but two pieces of a larger goal. Read this book and use its arguments to take the fight to smash capitalism, oppression, and domination in all its forms! (shrink)

This article focuses on the anxiety about whether God loves one or not. In the author's nearly 30-year ministry, this pastoral difficulty continues to perplex and afflict. While the presenting problem is what in theological parlance is 'a lack of assurance', a side difficulty is the poor and incorrect doctrine of God often associated with this. A Baylor University Study in 2006 characterises the kind of God that different groups of Americans believe in. While the phrase 'a lack of assurance' (...) is a part of dogmatic parlance, and has fallen out of use, the feeling of not belonging to God can be overwhelming for people. This feeling may be overwhelming. This makes it a pastoral issue. This article suggests a pastoral response to this issue and a proposal for a clarification in the nature and character of God using the therapeutic theology of 19th-century Scottish minister-theologian John McLeod Campbell. (shrink)

The existential analysis -- The death of dasein -- The timeliness of dasein -- The derivation of time -- The time of being.

Previous research has shown that subliminally presented stimuli accelerate or delay responses afforded by supraliminally presented stimuli. Our experiments extend these findings by showing that unconscious stimuli even affect free choices between responses. Thus, actions that are phenomenally experienced as freely chosen are influenced without the actor becoming aware of the manipulation. However, the unconscious influence is limited to a response bias, as participants chose the primed response only in up to 60% of the trials. LRP data in free choice (...) trials indicate that the prime was not ineffective in trials in which participants chose the non-primed response as then it delayed performance of the incongruently primed response. (shrink)